… of PAMPs and trigger the release of pro-inflammatory cytokines. … that cigarette smoke extract
can directly upregulate … MRC5, human lung fibroblasts cell line, exposed to cigarette smoke. …

… inflammation in the human lung fibroblast cell line HFL1. The … stimulate the expression of
apoptosis-specific genes through … been reported to upregulate DUSP16 expression and inhibit …

… of large amounts of pro-inflammatory cytokines, chemokines, … In line with our RNAseq results,
silencing of BRD3 induced … ], and increases oxidative stress in fibroblasts [48]. Among BET …

… expression of MMP1, 3 and 15 in fibroblast-like synoviocytes. … Therefore, inhibiting pro-inflammatory
cytokines or … In RA patients, upregulation of miR-146a causes persistent production …

… by excessive production of proinflammatory cytokines secrete … of grapes [93] and that increases
the expression of heme oxygenase-1 (… of MMP-3 and IL-1b in fibroblast-like synoviocytes. …

… were measured in RA human fibroblast-like synoviocytes (… is activated by pro-inflammatory
cytokines that facilitate the … As expected, the TNF-α treatment promoted the upregulation of NF-…

… to proinflammatory cytokines, cellproliferation, production of … (AREG) compared to fibroblast-like
synoviocytes from healthy … , increased expression of molecules and cytokines increases …

… and increases the vascularity and infiltration of immune cells, hence activating the fibroblast-like
… with its ligand upregulates the expression of proinflammatory cytokines. Inhibiting CD99 …

… Protein expression and phosphorylation were assessed … (eg smoking and infection) and
genetic (eg protein tyrosine … found to upregulate the production of pro-inflammatory cytokines (IL-…

… also induces neutrophilic inflammation and the production of … In contrast, in rheumatoid
fibroblast-like synoviocytes … as well as the production of proinflammatory cytokines after candida …